Fever of unknown origin fuo is defined as the presence of fever in a child for eight or more days that a careful history and physical examination and prel. Studies in any language were included if they provided the diagnosis in a series of 10 or more children with fuo. Fever of unknown origin fuo in adults is defined as a temperature higher than 38. Fever of unknown origin fuo refers to a prolonged febrile illness without an established etiology despite thorough evaluation. A specific discussion of the common and uncommon entities causing fuo and the approach to children with fuo is presented separately. Fever occurs when the bodys temperature is elevated as a result o. In previous studies, infectious disease was the most common cause of pediatric fever of. Infection is the most common cause of fever in children. Fever of unknown origin fuo in children approach to.
Assessment of fever in children approach bmj best practice. Pdf clinical approach to fever of unknown origin in children. The etiology of fuo varies markedly among different age groups, geographic areas, and seasons. Approach to the adult patient with fever of unknown origin. Pediatric fever of unknown origin american academy of. Pediatricians often confuse fever without a source and fever of unknown origin. Fever of unknown origin fuo, refers to a condition in which the patient has an elevated temperature fever but despite investigations by a physician no. Etiology and clinical characteristics of fever of unknown origin in. A fourstage investigative protocol for fuo is widely applied in clinical practice.
Fever is one of the most common symptoms in children. The initial diagnostic approach of the fuo patient should include. Clinical approach to fever of unknown origin in children. See etiologies of fever of unknown origin in adults and fever of unknown origin in children. The definition of fuo in the pediatric age group varies, with a time frame ranging from weeks in the literature.
After completing this article, readers should be able to. Fever of unknown origin in children world journal of pediatrics. Fever is a common symptom of many clinical conditions, and infection is the most common cause, especially in children. Evaluation of fever of unknown origin subacute presentation fever of unknown origin is not well defined in children and has been historically used to describe a subacute presentation of a single illness of at least 3 weeks duration during which a fever 38. Fever of unknown origin in children aged three months to fifteen. Adopt a systematic approach to evaluation and management of fever of unknown origin in patients of various ages. Fever of unknown origin fuo can be caused by many clinical conditions and remains a diagnostic challenge in clinical practice.
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